PReS-FINAL-2013: Sodium thiosulfate for the treatment of Juvenile Dermatomyositis complicated by calcinosis
نویسندگان
چکیده
Introduction Juvenile Dermatomyositis (JDM) is an inflammatory myopathy with a predilection for proximal muscles and skin. Current treatment of JDM includes early aggressive use of corticosteroids coupled with immunosuppressive drugs such as methotrexate, cyclosporine and intravenous immune globulins (IVIG). Delay to diagnosis and inadequate treatment increase the risk of developing calcinosis. However, once estabilished, this complication is difficult to treat.
منابع مشابه
PReS-FINAL-2275: Improvement of calcinosis cutis with intravenous pamidronate in a 2-year-old girl with progressive widespread skin calcification of unknown origin
Introduction Pathologic calcification occurs in up to 40% of children with juvenile dermatomyositis and can develop within several months even in successfully treated patients. Other differential diagnoses of calcinosis cutis in children are rare. There is no generally accepted standard treatment of calcinosis. We report on a 2-year-old previously healthy girl, the 2 child of non-consanguineous...
متن کاملAssessment, classification and treatment of calcinosis as a complication of juvenile dermatomyositis: a survey of pediatric rheumatologists by the childhood arthritis and rheumatology research alliance (CARRA)
BACKGROUND There is no standardized approach to the management of JDM-associated calcinosis and its phenotypes. Current knowledge of treatment outcomes is confined to small series and case reports. We describe physician perspectives toward diagnostic approach, classification and treatment directly targeting calcinosis, independent of overall JDM therapy. METHODS An electronic survey of 22 que...
متن کاملPReS-FINAL-2008: Juvenile dermatomyositis: a report of 22 cases
Methods Patients diagnosed of Juvenile dermatomyositis in La Fe Hospital (Valencia, Spain) since June 1992 to March 2013. Dates are shown in median and interquartile range for non-parametric variables, and for parametric variables is given as mean and standard deviation. To assess response to treatment, we used Wilcoxon test for paired measures of non-parametric variables and t-student for para...
متن کاملTreatment of calcinosis with biphosphonates in juvenile dermatomyositis
Juvenile dermatomyositis (JDM) is a multisystem disease that is characterized by nonsuppurative inflammation of striated muscle and skin. Dystrophic calcification occurs in up to 40% of children We present our treatment approach in four JDM patients with calcinosis. Four female patients (median age 8.5 years, range 6–14) had been diagnosed as JDM in our center. Two of them presented with severe...
متن کاملPReS-FINAL-2193: Assessment of construct validity of new measures of global disease activity, physical function and quality of life in children with juvenile dermatomyositis
Introduction Juvenile dermatomyositis (JDM) is a multisystem vasculopathic disease that affects primarily the skin and muscle and is characterized by high risk of morbidity and long-term damage. Regular patient assessment through standardized quantitative clinical measures is important to monitor the disease course over time and to evaluate treatment effectiveness. However, only a few outcome m...
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عنوان ژورنال:
دوره 11 شماره
صفحات -
تاریخ انتشار 2013